49. C. H. J. Choi, W. Barr, S. Zaman, C. Model, A. Park, M. Koenen, Z. Lin, S. K. Szwed, F. Marchildon, A. Crane, T. S. Carroll, H. Molina, P. Cohen. LRG1 is an adipokine that promotes insulin sensitivity and suppresses inflammation. eLife 11:e81559 (2022).

48. X. Huang, O. A. Maguire, J. M. Walker, C. S. Jiang, T. S. Carroll, J.-D. Luo, E. Tonorezos, D. N. Friedman, P. Cohen. Therapeutic radiation exposure of the abdomen during childhood induces chronic adipose tissue dysfunction. JCI Insight. 6(21):e153586 (2021).

47. O. A. Maguire, S. E. Ackerman, S. K. Szwed, A. V. Maganti, F. Marchildon, X. Huang, D. J. Kramer, A. Rosas-Villegas, R. G. Gelfer, L. E. Turner, V. Ceballos, A. Hejazi, B. Samborska, J. F. Rahbani, C. B. Dykstra, M. G. Annis, J.-D. Luo, T. S. Carroll, C. S. Jiang, A. J. Dannenberg, P. M. Siegel, S. A. Tersey, R. G. Mirmira, L. Kazak, P. Cohen, Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer. Cell Metabolism. 33, 499-512 (2021).

46. J. Chi, Z. Lin, W. Barr, A. Crane, X. G. Zhu, P. Cohen, Early postnatal interactions between beige adipocytes and sympathetic neurites regulate innervation of subcutaneous fat. eLife. 10, e64693 (2021).

45. F. Marchildon, J. Chi, S. O’Connor, H. Bediako, P. Cohen, Beige fat is dispensable for the metabolic benefits associated with myostatin deletion. Molecular Metabolism. 43, 101120 (2021).

44. T. Becher, S. Palanisamy, D. J. Kramer, M. Eljalby, S. J. Marx, A. G. Wibmer, S. D. Butler, C. S. Jiang, R. Vaughan, H. Schöder, A. Mark, P. Cohen, Brown adipose tissue is associated with cardiometabolic health. Nature Medicine. 27, 58–65 (2021).

43. K. Makwana, H. Chodavarapu, N. Morones, J. Chi, W. Barr, E. Novinbakht, Y. Wang, P. T. Nguyen, P. Jovanovic, P. Cohen, C. E. Riera, Sensory neurons expressing calcitonin gene-related peptide α regulate adaptive thermogenesis and diet-induced obesity. Molecular Metabolism. 45, 101161 (2021).

42. C. Campbell, F. Marchildon, A. J. Michaels, N. Takemoto, J. van der Veeken, M. Schizas, Y. Pritykin, C. S. Leslie, A. M. Intlekofer, P. Cohen, A. Y. Rudensky, FXR mediates T cell-intrinsic responses to reduced feeding during infection. PNAS. 117, 33446–33454 (2020).

41. F. Henriques, A. H. Bedard, A. Guilherme, M. Kelly, J. Chi, P. Zhang, L. M. Lifshitz, K. Bellvé, L. A. Rowland, B. Yenilmez, S. Kumar, Y. Wang, J. Luban, L. S. Weinstein, J. D. Lin, P. Cohen, M. P. Czech, Single-Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis. Cell Rep. 32, 107998 (2020).

40. L. Kazak, P. Cohen, Creatine metabolism: energy homeostasis, immunity and cancer biology. Nature Reviews Endocrinology. 16, 421–436 (2020).

39. P. Wang, K. H. Loh, M. Wu, D. A. Morgan, M. Schneeberger, X. Yu, J. Chi, C. Kosse, D. Kim, K. Rahmouni, P. Cohen, J. Friedman, A leptin–BDNF pathway regulating sympathetic innervation of adipose tissue. Nature. 583, 839–844 (2020).

38. T. Becher, D. F. Riascos-Bernal, D. J. Kramer, V. M. Almonte, J. Chi, T. Tong, G. H. Oliveira-Paula, I. Koleilat, W. Chen, P. Cohen, N. E. S. Sibinga, Three-Dimensional Imaging Provides Detailed Atherosclerotic Plaque Morphology and Reveals Angiogenesis After Carotid Artery Ligation. Circ Res. 126, 619–632 (2020).

37. M. M. Holter, D. Garibay, S. A. Lee, M. Saikia, A. K. McGavigan, L. Ngyuen, E. S. Moore, E. Daugherity, P. Cohen, K. Kelly, R. S. Weiss, B. P. Cummings, Hepatocyte p53 ablation induces metabolic dysregulation that is corrected by food restriction and vertical sleeve gastrectomy in mice. FASEB J. 34, 1846–1858 (2020).

36. M. Schneeberger, L. Parolari, T. Das Banerjee, V. Bhave, P. Wang, B. Patel, T. Topilko, Z. Wu, C. H. J. Choi, X. Yu, K. Pellegrino, E. A. Engel, P. Cohen, N. Renier, J. M. Friedman, A. R. Nectow, Regulation of Energy Expenditure by Brainstem GABA Neurons. Cell. 178, 672-685.e12 (2019).

35. W. Wang, J. Ishibashi, S. Trefely, M. Shao, A. J. Cowan, A. Sakers, H.-W. Lim, S. O’Connor, M. T. Doan, P. Cohen, J. A. Baur, M. T. King, R. L. Veech, K.-J. Won, J. D. Rabinowitz, N. W. Snyder, R. K. Gupta, P. Seale, A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate. Cell Metab. 30, 174-189.e5 (2019).

34. H. M. Silva, A. Báfica, G. F. Rodrigues-Luiz, J. Chi, P. d’Emery A. Santos, B. S. Reis, D. P. Hoytema van Konijnenburg, A. Crane, R. D. N. Arifa, P. Martin, D. A. G. B. Mendes, D. S. Mansur, V. J. Torres, K. Cadwell, P. Cohen, D. Mucida, J. J. Lafaille, Vasculature-associated fat macrophages readily adapt to inflammatory and metabolic challenges. J Exp Med. 216, 786–806 (2019).

33. S. J. Marx, P. Cohen, Thermogenic fat. Biochim Biophys Acta Mol Cell Biol Lipids. 1864, 1–2 (2019).

32. D. N. Friedman, E. S. Tonorezos, P. Cohen, Diabetes and Metabolic Syndrome in Survivors of Childhood Cancer. Horm Res Paediatr. 91, 118–127 (2019).

31. J. Chi, A. Crane, Z. Wu, P. Cohen, Adipo-Clear: A Tissue Clearing Method for Three-Dimensional Imaging of Adipose Tissue. Journal of Visualized Experiments (2018).

30. M. J. Khandekar, A. S. Banks, D. Laznik-Bogoslavski, J. P. White, J. H. Choi, L. Kazak, J. C. Lo, P. Cohen, K.-K. Wong, T. M. Kamenecka, P. R. Griffin, B. M. Spiegelman, Noncanonical agonist PPARγ ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy. Proc Natl Acad Sci U S A. 115, 561–566 (2018).

29. Y. Hasegawa, K. Ikeda, Y. Chen, D. L. Alba, D. Stifler, K. Shinoda, T. Hosono, P. Maretich, Y. Yang, Y. Ishigaki, J. Chi, P. Cohen, S. K. Koliwad, S. Kajimura, Repression of Adipose Tissue Fibrosis through a PRDM16-GTF2IRD1 Complex Improves Systemic Glucose Homeostasis. Cell Metab. 27, 180-194.e6 (2018).

28. J. Chi, Z. Wu, C. H. J. Choi, L. Nguyen, S. Tegegne, S. E. Ackerman, A. Crane, F. Marchildon, M. Tessier-Lavigne, P. Cohen, Three-Dimensional Adipose Tissue Imaging Reveals Regional Variation in Beige Fat Biogenesis and PRDM16-Dependent Sympathetic Neurite Density. Cell Metab. 27, 226-236.e3 (2018).

27. C. H. J. Choi, P. Cohen, How does obesity lead to insulin resistance? Elife. 6 (2017), doi:10.7554/eLife.33298.

26. J. F. O’Sullivan, J. E. Morningstar, Q. Yang, B. Zheng, Y. Gao, S. Jeanfavre, J. Scott, C. Fernandez, H. Zheng, S. O’Connor, P. Cohen, R. S. Vasan, M. T. Long, J. G. Wilson, O. Melander, T. J. Wang, C. Fox, R. T. Peterson, C. B. Clish, K. E. Corey, R. E. Gerszten, Dimethylguanidino valeric acid is a marker of liver fat and predicts diabetes. J Clin Invest. 127, 4394–4402 (2017).

25. C. H. J. Choi, P. Cohen, Adipose crosstalk with other cell types in health and disease. Exp Cell Res. 360, 6–11 (2017).

24. S. E. Ackerman, O. A. Blackburn, F. Marchildon, P. Cohen, Insights into the Link Between Obesity and Cancer. Curr Obes Rep. 6, 195–203 (2017).

23. Z. F. Huang Cao, E. Stoffel, P. Cohen, Role of Perivascular Adipose Tissue in Vascular Physiology and Pathology. Hypertension. 69, 770–777 (2017).

22. M. M. A. Pereira, I. Mahú, E. Seixas, N. Martinéz-Sánchez, N. Kubasova, R. M. Pirzgalska, P. Cohen, M. O. Dietrich, M. López, G. J. L. Bernardes, A. I. Domingos, A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages. Nat Commun. 8, 14967 (2017).

21. S. O’Connor, P. Cohen, In Vitro Approaches to Model and Study Communication Between Adipose Tissue and the Liver. Methods Mol Biol. 1566, 151–158 (2017).

20. P. Cohen, B. M. Spiegelman, Cell biology of fat storage. Mol Biol Cell. 27, 2523–2527 (2016).

19. K. J. Svensson, J. Z. Long, M. P. Jedrychowski, P. Cohen, J. C. Lo, S. Serag, S. Kir, K. Shinoda, J. A. Tartaglia, R. R. Rao, A. Chédotal, S. Kajimura, S. P. Gygi, B. M. Spiegelman, A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function. Cell Metab. 23, 454–466 (2016).

18. J. Chi, P. Cohen, The Multifaceted Roles of PRDM16: Adipose Biology and Beyond. Trends Endocrinol Metab. 27, 11–23 (2016).

17. L. Kazak, E. T. Chouchani, M. P. Jedrychowski, B. K. Erickson, K. Shinoda, P. Cohen, R. Vetrivelan, G. Z. Lu, D. Laznik-Bogoslavski, S. C. Hasenfuss, S. Kajimura, S. P. Gygi, B. M. Spiegelman, A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat. Cell. 163, 643–655 (2015).

16. P. Cohen, B. M. Spiegelman, Brown and Beige Fat: Molecular Parts of a Thermogenic Machine. Diabetes. 64, 2346–2351 (2015).

15. S. Kir, J. P. White, S. Kleiner, L. Kazak, P. Cohen, V. E. Baracos, B. M. Spiegelman, Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia. Nature. 513, 100–104 (2014).

14. J. C. Lo, S. Ljubicic, B. Leibiger, M. Kern, I. B. Leibiger, T. Moede, M. E. Kelly, D. Chatterjee Bhowmick, I. Murano, P. Cohen, A. S. Banks, M. J. Khandekar, A. Dietrich, J. S. Flier, S. Cinti, M. Blüher, N. N. Danial, P.-O. Berggren, B. M. Spiegelman, Adipsin is an adipokine that improves β cell function in diabetes. Cell. 158, 41–53 (2014).

13. X. Kong, A. Banks, T. Liu, L. Kazak, R. R. Rao, P. Cohen, X. Wang, S. Yu, J. C. Lo, Y.-H. Tseng, A. M. Cypess, R. Xue, S. Kleiner, S. Kang, B. M. Spiegelman, E. D. Rosen, IRF4 is a key thermogenic transcriptional partner of PGC-1α. Cell. 158, 69–83 (2014).

12. P. Cohen, J. D. Levy, Y. Zhang, A. Frontini, D. P. Kolodin, K. J. Svensson, J. C. Lo, X. Zeng, L. Ye, M. J. Khandekar, J. Wu, S. C. Gunawardana, A. S. Banks, J. P. G. Camporez, M. J. Jurczak, S. Kajimura, D. W. Piston, D. Mathis, S. Cinti, G. I. Shulman, P. Seale, B. M. Spiegelman, Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell. 156, 304–316 (2014).

11. J. Wu, P. Cohen, B. M. Spiegelman, Adaptive thermogenesis in adipocytes: is beige the new brown? Genes Dev. 27, 234–250 (2013).

10. L. Ye, S. Kleiner, J. Wu, R. Sah, R. K. Gupta, A. S. Banks, P. Cohen, M. J. Khandekar, P. Boström, R. J. Mepani, D. Laznik, T. M. Kamenecka, X. Song, W. Liedtke, V. K. Mootha, P. Puigserver, P. R. Griffin, D. E. Clapham, B. M. Spiegelman, TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell. 151, 96–110 (2012).

9. M. J. Khandekar, P. Cohen, B. M. Spiegelman, Molecular mechanisms of cancer development in obesity. Nat Rev Cancer. 11, 886–895 (2011).

8. K. Birsoy, A. Soukas, J. Torrens, G. Ceccarini, J. Montez, M. Maffei, P. Cohen, G. Fayzikhodjaeva, A. Viale, N. D. Socci, J. M. Friedman, Cellular program controlling the recovery of adipose tissue mass: An in vivo imaging approach. Proc Natl Acad Sci U S A. 105, 12985–12990 (2008).

7. P. Cohen, G. Yang, X. Yu, A. A. Soukas, C. S. Wolfish, J. M. Friedman, C. Li, Induction of leptin receptor expression in the liver by leptin and food deprivation. J Biol Chem. 280, 10034–10039 (2005).

6. P. Cohen, J. M. Friedman, Leptin and the control of metabolism: role for stearoyl-CoA desaturase-1 (SCD-1). J Nutr. 134, 2455S-2463S (2004).

5. E. Asilmaz, P. Cohen, M. Miyazaki, P. Dobrzyn, K. Ueki, G. Fayzikhodjaeva, A. A. Soukas, C. R. Kahn, J. M. Ntambi, N. D. Socci, J. M. Friedman, Site and mechanism of leptin action in a rodent form of congenital lipodystrophy. J Clin Invest. 113, 414–424 (2004).

4. P. Cohen, J. M. Ntambi, J. M. Friedman, Stearoyl-CoA desaturase-1 and the metabolic syndrome. Curr Drug Targets Immune Endocr Metabol Disord. 3, 271–280 (2003).

3. P. Cohen, M. Miyazaki, N. D. Socci, A. Hagge-Greenberg, W. Liedtke, A. A. Soukas, R. Sharma, L. C. Hudgins, J. M. Ntambi, J. M. Friedman, Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science. 297, 240–243 (2002).

2. P. Cohen, C. Zhao, X. Cai, J. M. Montez, S. C. Rohani, P. Feinstein, P. Mombaerts, J. M. Friedman, Selective deletion of leptin receptor in neurons leads to obesity. J Clin Invest. 108, 1113–1121 (2001).

1. A. Soukas, P. Cohen, N. D. Socci, J. M. Friedman, Leptin-specific patterns of gene expression in white adipose tissue. Genes Dev. 14, 963–980 (2000).