2026
Karandikar N, Beyer-Teal C, Yue L, Kilic E, Lin Z, Yammine L, Morozova K, Hadley CK, Barber S, McGraw TE, Cohen P. Brown adipose tissue sustains thermogenesis through metabolic flexibility in glucose utilization. Nat Metab. 2026. Accepted for publication.
Gomez-Banoy N, Barrero JA, Pinheiro de Carvalho LR, Jiang C, Lama TD, Karandikar N, Koenen M, Lam T, Plucinska K, Morozova K, Chahwan S, Barraza G, Ucpinar BA, Liu JE, Sharma R, Lafontaine D, Schoder H, Cohen P. Artifical intelligence-enabled clinical phenotyping of human brown fat. Nature. 2026. doi: 10.1038/s41586-026-11162-7.
Koenen M, Becher T, Pagano G, Del Gaudio I, Barrero JA, Montezano AC, Ruiz Ortiz J, Lin Z, Gómez-Banoy N, Amblard R, Schriever D, Kars ME, Rubinelli L, Halix SJ, Huang Cao ZF, Zeng X, Butler SD, Itan Y, Touyz RM, Di Lorenzo A, Cohen P. Ablation of Prdm16 and beige fat identity causes vascular remodeling and elevated blood pressure. Science. 2026;391(6782):306-313. doi: 10.1126/science.ady8644.
Olsen L, Botella J, Barrows D, Romero E, Baird K, Katayama M, Kilic E, Peralta C, Zanou N, Sanford H, Farrell L, Axelrod CL, Plucińska K, Walker J, Yan L, Fredrickson K, Pourquie O, Robbins JM, Vinogradova EV, Molina H, Place N, Kirwan JP, Zierath JR, Krook A, Gerszten RE, Bishop DJ, Cohen P. Exercise intensity modulates interorgan communication and is associated with cardiometabolic health outcomes in humans. Cell Rep Med. 2026;102988. doi: 10.1016/j.xcrm.2026.102988.
Plucińska K, Wayne CR, Sanford H, Mathew B, Ropek N, Adaniya SM, Model C, Gómez-Banoy N, Morozova K, Cao X, Friedman JM, Loh KH, Cohen P, Vinogradova EV. Cell-type-specific proximity labeling of organ secretomes reveals energy balance-dependent proteomic remodeling. Cell Rep. 2026;45(6):117507. doi: 10.1016/j.celrep.2026.117507.
Karavaeva I, Basse AL, Trammell SAJ, Hussain MF, Markussen LK, Havelund JF, Isidor MS, Chatoff A, Huacachino AA, Richter HJ, Birla M, Chubanava S, Deleye Y, Arianti R, Tandio D, Utzon SE, Kaiser Z, Shen Y, Neess D, Embring H, Menon D, Conway OJ, Sass F, Finger F, Muntadas LA, Ma T, Sustarsic EG, Kristensen CK, McIntyre RL, Martinez GJ, Husted AS, Emmett MJ, Kipp ZA, Frost M, Jedrychowski MP, van Weeghel M, Majd H, Zhuravleva E, McGarrah RW, Plucinska K, Midha MK, Prokesch A, Cohen P, Granneman JG, Seale P, Houtkooper RH, Hansen JB, Gygi SP, Schwartz TW, Gillum MP, Hinds, Jr. TD, Soccio RE, White PJ, Kunji ERS, Moritz T, Treebak JT, Kristóf E, Mandrup S, Emanuelli B, Snyder NW, Fazakerley DJ, Kazak L, Færgeman NJ, Lazar MA, Gerhart-Hines Z. Mitochondrial carrier SLC35A4 links clock, diet, and temperature control of adipocyte lipid cycling. Science. 2026;394(6819):eadz4797. doi: 10.1126/science.adz4797.
Serdan TDA, Cervantes H, Frank B, Iragavarapu AG, Tian Q, Hope D, Choi CHJ, Hoffmann A, Ghosh A, Wolfrum C, Greenblatt MB, Cohen P, Blüher M, Aydin H, Schwartz GJ, Shamsi F. SLIT3 fragments orchestrate neurovascular expansion and thermogenesis in brown adipose tissue. Nat Commun. 2026;17(1). doi: 10.1038/s41467-026-70310-9.
Moura-Assis A, Plucińska K, Meseguer D, Baleisyte A, Chen B, Pellegrino K, Parolari L, Shaked JT, Page KJ, Barrows DW, Carroll TS, Grajales-Reyes JG, Na D, Rodriguez-Diaz A, Furtado J, Isaza JU, Schiffer HH, Chen Y, Sun H, Kaushal N, Monenschein H, Barker DF, Ortuño MJ, Renier N, Cohen P, Carlton M, Heintz N, Brice NL, Friedman JM, Schneeberger M. Identification of a thermogenic target in the dorsal raphe nucleus for weight management in mice. Nat Commun. 2026;17(1):1295. doi: 10.1038/s41467-025-68056-x.
2025
Rocha AL, Schmedt C, Perkins G, Pinto A, Diedrich JK, Shan H, Plucińska K, Vieira de Souza E, Vaughan JM, Foster M, Sampath SC, Sampath SC, Cohen P, Ellisman MH, Saghatelian A. Abnormal mitochondrial structure and function in brown adipose tissue of SLC35A4-MP knockout mice. Sci Adv. 2025;11(35):eads7381. doi: 10.1126/sciadv.ads7381.
Lafontaine D, Chahwan S, Barraza G, Ucpinar BA, Kayal G, Gómez-Banoy N, Cohen P, Humm JL, Schöder H. Brown adipose tissue machine learning nnU-Net V2 network using TriDFusion (3DF). EJNMMI Res. 2025;15(1):108. doi: 10.1186/s13550-025-01303-w.
Kaplan JP, Ye W, Kileen H, Liang Z, Tran A, Chi J, Yang C, Cohen P, Liman ER. Epitope tagging with genome editing in mice reveals that the proton channel OTOP1 is apically localized and not restricted to type III “sour” taste receptor cells. J Neurosci. 2025;45(6). doi: 10.1523/JNEUROSCI.1560-24.2024. PMID: 39592233; PMCID: PMC11800744.
2024
Tan HL, Yin L, Tan Y, Ivanov J, Plucinska K, Ilanges A, Herb BR, Wang P, Kosse C, Cohen P, Lin D, Friedman JM. Leptin activated hypothalamic BNC2 neurons acutely suppress food intake. Nature. 2024;636(8041):198-205. doi: 10.1038/s41586-024-08108-2.
Li Z, Shi B, Li N, Sun J, Zeng X, Huang R, Bok S, Chen X, Han J, Yallowitz AR, Debnath S, Cung M, Ling Z, Zhong CQ, Hong Y, Li G, Koenen M, Cohen P, Su X, Lu H, Greenblatt MB, Xu R. Bone controls browning of white adipose tissue and protects from diet-induced obesity through Schnurri-3-regulated SLIT2 secretion. Nat Commun. 2024;15(1):6697. doi: 10.1038/s41467-024-51155-6.
Gómez-Banoy N, Ortiz EJ, Jiang CS, Dagher C, Sevilla C, Girshman J, Pagano AM, Plodkowski AJ, Zammarrelli WA, Mueller JJ, Aghajanian C, Weigelt B, Makker V, Cohen P, Osorio JC. Body mass index and adiposity influence the response to immune checkpoint inhibition in endometrial cancer. J Clin Invest. 2024 Jun 20;134(17). doi: 10.1172/JCI180516.
Li E, Wang L, Wang D, Chi J, Lin Z, Smith GI, Klein S, Cohen P, Rosen ED. Control of lipolysis by a population of oxytocinergic sympathetic neurons. Control of lipolysis by a population of oxytocinergic sympathetic neurons. Nature. 2024;625(7993):175-180. doi: 10.1038/s41586-023-06830-x.
2023
M. Eljalby, X, Huang, T. Becher, A.G. Wibmer, C.S. Jiang, R. Vaughan, H. Schöder, and P. Cohen. Brown adipose tissue is not associated with cachexia or increased mortality in a retrospective study of patients with cancer. Am J Physiol Endocrinol Metab. 324, E144-E153 (2023).
2022
C. H. J. Choi, W. Barr, S. Zaman, C. Model, A. Park, M. Koenen, Z. Lin, S. K. Szwed, F. Marchildon, A. Crane, T. S. Carroll, H. Molina, P. Cohen. LRG1 is an adipokine that promotes insulin sensitivity and suppresses inflammation. eLife 11:e81559 (2022).
2021
M. Koenen, M.A. Hill, P. Cohen, J.R. Sowers. Obesity, Adipose Tissue and Vascular Dysfunction. Circ Res. 128, 951-968 (2021).
X. Huang, O. A. Maguire, J. M. Walker, C. S. Jiang, T. S. Carroll, J.-D. Luo, E. Tonorezos, D. N. Friedman, P. Cohen. Therapeutic radiation exposure of the abdomen during childhood induces chronic adipose tissue dysfunction. JCI Insight. 6(21):e153586 (2021).
O. A. Maguire, S. E. Ackerman, S. K. Szwed, A. V. Maganti, F. Marchildon, X. Huang, D. J. Kramer,A. Rosas-Villegas, R. G. Gelfer, L. E. Turner, V. Ceballos, A. Hejazi, B. Samborska, J. F. Rahbani, C. B. Dykstra, M. G. Annis, J.-D. Luo, T. S. Carroll, C. S. Jiang, A. J. Dannenberg, P. M. Siegel, S. A. Tersey, R. G. Mirmira, L. Kazak, P. Cohen. Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer. Cell Metab. 33, 499-512 (2021).
J. Chi, Z. Lin, W. Barr, A. Crane, X. G. Zhu, P. Cohen. Early postnatal interactions between beige adipocytes and sympathetic neurites regulate innervation of subcutaneous fat. eLife. 10, e64693 (2021).
F. Marchildon, J. Chi, S. O’Connor, H. Bediako, P. Cohen. Beige fat is dispensable for the metabolic benefits associated with myostatin deletion. Mol Metab. 43, 101120 (2021).
A.G. Wibmer, T. Becher, M. Eljalby, A. Crane, P.C. Andrieu, C.S. Jiang, R. Vaughan, H. Schöder, P. Cohen. Brown adipose tissue is associated with healthier body fat distribution and metabolic benefits independent of regional adiposity.
Cell Rep Med. 2, 100332 (2021).
T. Becher, S. Palanisamy, D. J. Kramer, M. Eljalby, S. J. Marx, A. G. Wibmer, S. D. Butler, C. S. Jiang, R. Vaughan, H. Schöder, A. Mark, P. Cohen, Brown adipose tissue is associated with cardiometabolic health. Nat Medicine. 27, 58–65 (2021).
K. Makwana, H. Chodavarapu, N. Morones, J. Chi, W. Barr, E. Novinbakht, Y. Wang, P. T. Nguyen, P. Jovanovic, P. Cohen, C. E. Riera. Sensory neurons expressing calcitonin gene-related peptide α regulate adaptive thermogenesis and diet-induced obesity. Mol Metab. 45, 101161 (2021).
2020
C. Campbell, F. Marchildon, A. J. Michaels, N. Takemoto, J. van der Veeken, M. Schizas, Y. Pritykin, C. S. Leslie, A. M. Intlekofer, P. Cohen, A. Y. Rudensky, FXR mediates T cell-intrinsic responses to reduced feeding during infection. PNAS. 117, 33446–33454 (2020).
F. Henriques, A. H. Bedard, A. Guilherme, M. Kelly, J. Chi, P. Zhang, L. M. Lifshitz, K. Bellvé, L. A. Rowland, B. Yenilmez, S. Kumar, Y. Wang, J. Luban, L. S. Weinstein, J. D. Lin, P. Cohen, M. P. Czech, Single-Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis. Cell Rep. 32, 107998 (2020).
L. Kazak, P. Cohen, Creatine metabolism: energy homeostasis, immunity and cancer biology. Nature Reviews Endocrinology. 16, 421–436 (2020).
39. P. Wang, K. H. Loh, M. Wu, D. A. Morgan, M. Schneeberger, X. Yu, J. Chi, C. Kosse, D. Kim, K. Rahmouni, P. Cohen, J. Friedman, A leptin–BDNF pathway regulating sympathetic innervation of adipose tissue. Nature. 583, 839–844 (2020).
T. Becher, D.F. Riascos-Bernal, D.J. Kramer, V. M. Almonte, J. Chi, T. Tong, G. H. Oliveira-Paula, I. Koleilat, W. Chen, P. Cohen, N. E. S. Sibinga, Three-Dimensional Imaging Provides Detailed Atherosclerotic Plaque Morphology and Reveals Angiogenesis After Carotid Artery Ligation. Circ Res. 126, 619–632 (2020).
M. M. Holter, D. Garibay, S. A. Lee, M. Saikia, A. K. McGavigan, L. Ngyuen, E. S. Moore, E. Daugherity, P. Cohen, K. Kelly, R. S. Weiss, B. P. Cummings, Hepatocyte p53 ablation induces metabolic dysregulation that is corrected by food restriction and vertical sleeve gastrectomy in mice. FASEB J. 34, 1846–1858 (2020).
2019
M. Schneeberger, L. Parolari, T. Das Banerjee, V. Bhave, P. Wang, B. Patel, T. Topilko, Z. Wu, C.H J. Choi, X. Yu, K. Pellegrino, E. A. Engel, P. Cohen, N. Renier, J. M. Friedman, A. R. Nectow, Regulation of Energy Expenditure by Brainstem GABA Neurons. Cell. 178, 672-685.e12 (2019).
W. Wang, J. Ishibashi, S. Trefely, M. Shao, A. J. Cowan, A. Sakers, H.-W. Lim, S. O’Connor, M. T. Doan, P. Cohen, J. A. Baur, M. T. King, R. L. Veech, K.-J. Won, J. D. Rabinowitz, N. W. Snyder, R. K. Gupta, P. Seale, A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate. Cell Metab. 30, 174-189.e5 (2019).
H. M. Silva, A. Báfica, G. F. Rodrigues-Luiz, J. Chi, P. d’Emery A. Santos, B. S. Reis, D. P. Hoytema van Konijnenburg, A. Crane, R. D. N. Arifa, P. Martin, D. A. G. B. Mendes, D. S. Mansur, V. J. Torres, K. Cadwell, P. Cohen, D. Mucida, J. J. Lafaille, Vasculature-associated fat macrophages readily adapt to inflammatory and metabolic challenges. J Exp Med. 216, 786–806 (2019).
S. J. Marx, P. Cohen, Thermogenic fat. Biochim Biophys Acta Mol Cell Biol Lipids. 1864, 1–2 (2019).
D. N. Friedman, E. S. Tonorezos, P. Cohen, Diabetes and Metabolic Syndrome in Survivors of Childhood Cancer. Horm Res Paediatr. 91, 118–127 (2019).
2018
J. Chi, A. Crane, Z. Wu, P. Cohen, Adipo-Clear: A Tissue Clearing Method for Three-Dimensional Imaging of Adipose Tissue. Journal of Visualized Experiments (2018).
M. J. Khandekar, A. S. Banks, D. Laznik-Bogoslavski, J. P. White, J. H. Choi, L. Kazak, J. C. Lo, P. Cohen, K.-K. Wong, T. M. Kamenecka, P. R. Griffin, B. M. Spiegelman, Noncanonical agonist PPARγ ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy. Proc Natl Acad Sci U S A. 115, 561–566 (2018).
Y. Hasegawa, K. Ikeda, Y. Chen, D. L. Alba, D. Stifler, K. Shinoda, T. Hosono, P. Maretich, Y. Yang, Y. Ishigaki, J. Chi, P. Cohen, S. K. Koliwad, S. Kajimura, Repression of Adipose Tissue Fibrosis through a PRDM16-GTF2IRD1 Complex Improves Systemic Glucose Homeostasis. Cell Metab. 27, 180-194.e6 (2018).
J. Chi, Z. Wu, C. H. J. Choi, L. Nguyen, S. Tegegne, S. E. Ackerman, A. Crane, F. Marchildon, M. Tessier-Lavigne, P. Cohen, Three-Dimensional Adipose Tissue Imaging Reveals Regional Variation in Beige Fat Biogenesis and PRDM16-Dependent Sympathetic Neurite Density. Cell Metab. 27, 226-236.e3 (2018).
2017
C. H. J. Choi, P. Cohen, How does obesity lead to insulin resistance? Elife. 6 (2017), doi:10.7554/eLife.33298.
J. F. O’Sullivan, J. E. Morningstar, Q. Yang, B. Zheng, Y. Gao, S. Jeanfavre, J. Scott, C. Fernandez, H. Zheng, S. O’Connor, P. Cohen, R. S. Vasan, M. T. Long, J. G. Wilson, O. Melander, T. J. Wang, C. Fox, R. T. Peterson, C. B. Clish, K. E. Corey, R. E. Gerszten, Dimethylguanidino valeric acid is a marker of liver fat and predicts diabetes. J Clin Invest. 127, 4394–4402 (2017).
C. H. J. Choi, P. Cohen, Adipose crosstalk with other cell types in health and disease. Exp Cell Res. 360, 6–11 (2017).
S. E. Ackerman, O. A. Blackburn, F. Marchildon, P. Cohen, Insights into the Link Between Obesity and Cancer. Curr Obes Rep. 6, 195–203 (2017).
Z. F. Huang Cao, E. Stoffel, P. Cohen, Role of Perivascular Adipose Tissue in Vascular Physiology and Pathology. Hypertension. 69, 770–777 (2017).
M. M. A. Pereira, I. Mahú, E. Seixas, N. Martinéz-Sánchez, N. Kubasova, R. M. Pirzgalska, P. Cohen, M. O. Dietrich, M. López, G. J. L. Bernardes, A. I. Domingos, A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages. Nat Commun. 8, 14967 (2017).
S. O’Connor, P. Cohen, In Vitro Approaches to Model and Study Communication Between Adipose Tissue and the Liver. Methods Mol Biol. 1566, 151–158 (2017).
2016
P. Cohen, B. M. Spiegelman, Cell biology of fat storage. Mol Biol Cell. 27, 2523–2527 (2016).
K. J. Svensson, J. Z. Long, M. P. Jedrychowski, P. Cohen, J. C. Lo, S. Serag, S. Kir, K. Shinoda, J. A. Tartaglia, R. R. Rao, A. Chédotal, S. Kajimura, S. P. Gygi, B. M. Spiegelman, A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function. Cell Metab. 23, 454–466 (2016).
J. Chi, P. Cohen, The Multifaceted Roles of PRDM16: Adipose Biology and Beyond. Trends Endocrinol Metab. 27, 11–23 (2016).